The Kuhner Nemiri automates the handling of sandwich covers and clamps (Duetz System) on deepwell microtiter plates (MTPs). By significantly reducing manual intervention, this innovative automated stand-alone lid clamping system increases process reliability and throughput. Sterility is rigorously maintained throughout the entire automated cell culture workflow, ensuring safe operation while allowing straightforward integration into existing laboratory automation systems.

Kuhner Nemiri has already been successfully integrated at the software level by a number of established automation partners and system integrators,  such as Peak Analysis & Automation (PAA) and Lab Services. . This allows for its seamless incorporation into existing or newly planned automated laboratory and bioprocessing workflows.

Human, animal, and insect cell culture is a demanding and long-running process. Over cultivation periods of four to eight days at 37 °C, evaporation of the culture medium can significantly impact cell culture performance and result quality. To minimize evaporation while maintaining an efficient oxygen transfer rate (OTR) and gas exchange, the Duetz System (from Enzyscreen) is widely used. It provides effective evaporation control without compromising oxygen transfer, helping to ensure consistent and reliable cultivation conditions.

However, up until now, the only available solution for high-throughput screening was manual work: an operator manually clamping and unclamping sandwich covers on each microtiter plate. The Kuhner Nemiri changes this paradigm.

Native integration into robotic workflows

The Kuhner Nemiri is designed for seamless integration into automated laboratory and biotech workflows. It can be effortlessly combined with collaborative robots, automated incubator shakers, liquid handling systems, plate readers, automated storage units, and robotic plate handling platforms. By strengthening process safety and reducing manual intervention, it helps maintain sterile and reproducible conditions while protecting valuable biological samples, development efforts, and existing laboratory automation investments.

Full compatibility with Enzyscreen’s sandwich cover portfolio

The Kuhner Nemiri offers maximum flexibility for automated microtiter plate workflows and is fully compatible with the complete portfolio of Enzyscreen’s sandwich covers (Duetz System). From proven stainless steel covers to ultra-lightweight carbon versions and convenient single-use solutions, the Kuhner Nemiri supports the right cover concept for every cultivation process.

Single-use sandwich covers provide a strong advantage for high-throughput screening (HTS) environments, especially where autoclaving large numbers of reusable covers is not practical or would create a bottleneck. By reducing cleaning and sterilization requirements, they enable a more efficient, scalable, and GMP-friendly workflow while supporting process consistency and operational reliability.

Continuous operation, 24/7

The Kuhner Nemiri brings a new level of continuity to automated cultivation workflows. It supports reliable operation around the clock, 365 days per year, reducing dependency on manual handling and enabling biotechnology laboratories to extend productivity beyond regular working hours, without increasing operational complexity or scaling the headcount.

Less manual handling, more consistent process conditions

In sensitive cell culture workflows, every manual handling step can introduce variability and increases the contamination risk. The Kuhner Nemiri automates the handling of  sandwich covers (from Enzyscreen), helping to preserve sterility and maintain consistent biological process conditions. This supports safe, reproducible workflows, regardless of operator availability, working hours, or shift changes.

Integrated clamp magazine for autonomous workflows

The Kuhner Nemiri features an integrated magazine that stores up to four clamps directly inside the unit, keeping them readily available whenever required during automated operation. This significantly reduces manual intervention, simplifies process logistics, and supports reliable workflow continuity.

In addition, the system can detect clamps without plates, allowing the magazine to be loaded and unloaded automatically in combination with plate hotels, robotic plate handlers, or other automation modules. At the start and end of the overall process, clamp handling can be fully automated ; for example, in tandem with the Kuhner MPS-Z Automated incubator and its capacity of up to 16 microtiter plates. This enables efficient magazine management and supports stable, unattended operation as part of a fully automated laboratory ecosystem.

The Kuhner Nemiri is a stand-alone automated clamping system that enables fully automated use of Enzyscreen’s sandwich covers and clamps (Duetz System) for microtiter plates. It clamps and unclamps sandwich covers for deepwell MTPs with precise, calibrated pressure to ensure hermetic isolation of each individual well, with absolute zero manual intervention.

Its stand-alone architecture integrates into any existing workflow and is highly compatible with labware handling robots, while stable plate positioning keeps cell cultures secure even at high agitation speeds. It is also designed to work seamlessly with the Kuhner MPS-Z Automated incubator.

The Kuhner Nemiri was purposefully designed to fit seamlessly into the Kuhner automation range. Together, these advanced instruments cover the full spectrum of automated cell culture: from microplates to tubes to shake flasks.

To ensure the seamless integration into existing and newly planned automated laboratory workflows, the Kuhner Nemiri has been successfully integrated at a software level by a number of established automation partners and system integrators, such as Peak Analysis & Automation and Lab Services.