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The new Kuhner microTOM elevates your screening on the fast track. This online monitoring tool empowers you to make fast, data-driven decisions during the critical early phases of process development — helping you identify the optimal strain or media composition quickly and reliably.
Kuhner microTOM is the next-generation online monitoring system for analyzing cellular respiration in microbial and cell culture applications — directly in 96- or 24-well microtiter plates. Using oxygen transfer rate (OTR) as a precise and scalable indicator, Kuhner microTOM offers automated, label-free screening — without manual sampling, without offline analysis, and without interruptions, even on weekends.
96 parallel OTR measurements – unrivaled throughput for microplate-based cultivation.
Low running costs –Only standard MTP and sealing membrane necessary, no expensive consumables
Compatible with all Kuhner shakers – and potentially third-party systems (Kuhner Atelier project)
Compact footprint – 96 monitored bioreactors at the size of a cryostorage box
Extremely sensitive – Next to microbes, it is also suitable for mammalian
No offline sampling required – fully automated & continuous measurement
Compatible with standard microplates
Patented technology adapted from proven Kuhner TOM systems
Robust data for Clone-, Media- or Process parameter screening
Ideal to monitor FeedPlate© – the fed-batch solution for MTPs
Online Measurement
Flexibility
Application
2-years warranty
The Kuhner microTOM Type M is specifically designed for use in non-humidified incubators. It features a fully integrated humidification and aeration system, ensuring stable and controlled environmental conditions for sensitive laboratory processes.
The system includes the Kuhner microTOM Supply Type M, the Sensor Type M, a dedicated humidification system, as well as comprehensive cable and tube management to maintain an organised and efficient workspace.
This compact and intelligent configuration makes it an ideal solution for laboratories requiring reliable humidification and precise control within small-scale incubator environments.
The Kuhner microTOM Type C is optimised for use in humidified incubators (w/wo CO₂ control), eliminating the need for an additional humidification system. Aeration is provided directly via the incubator air, simplifying operation and maintenance.
The system includes the Kuhner microTOM Supply Type C, the Sensor Type C, and a streamlined cable and tube management setup to ensure an efficient and well-organised workspace.
This configuration offers a practical and space-saving solution for laboratories operating in environments where integrated humidification is unnecessary.
Quantify cellular activity every 20 minutes* via OTR – a direct measure of metabolic respiration
No probes, no sensors in the liquid – fully non-invasive and unaffected by turbidity or morphology
OTR is independent of shaking conditions or oxygen solubility – unlike dissolved oxygen (DO) measurements
Correlates directly with substrate consumption and viable cell count (scientific publications available)
Cell behaviour und media performance, insight in media composition
Ideal for: clone screening, media optimization, toxicity studies, process development, and scale-up validation
*shortest measuring cycle possible.
The Kuhner microTOM is the only system on the market offering precise, high-throughput OTR monitoring in standard microtiter plates — with low costs, no manual labor, and full compatibility with your existing Kuhner setup.
Empower your bioprocess development and screening workflows — with Kuhner microTOM.
Temperature range | 15-40°C |
Shaking speed | up to 1000 rpm |
Orbital shaking diameter | 3 mm - 50 mm |
Microtiter plate format |
96-Deepwell (total height of microtiter plate 43 - 44 mm)
|
Microtiter plate geometry |
round well (RW) - square well (SW)
|
Filling volume | >100 μL |
Sterile barrier | Gas permeable non-woven Rayon foil with acrylate adhesive |
Ambient and aeration humidity | < 85% rel. humidity |
O2- concentration range | max. 30% v/v in inlet gas |
Maintenance | Calibration of O2 sensors before every experiment |
Warranty time | 2 years |
Technical data subject to change | |
Order No. | designation |
|---|---|
109886 | Sensor Modul Typ M |
109951 | Supply Modul Typ M |
109967 | Cable and hose management for Z generation |
109968 | Cable and hose management for X generation |
Order No. | designation |
|---|---|
109950 | Supply Modul Typ C |
109967 | Cable and hose management for Z generation |
109968 | Cable and hose management for X generation |
Metabolic studies of Ogataea polymorpha using nine different corn steep liquors (Sekar Mayang W. Wahjudi et al., BMC Biotechnology 2025)
Scale‑up of CHO cell cultures: from 96‑well‑microtiter plates to stirred tank reactors across three orders of magnitude (Anne Neuss et al., Journal of Biological Engineering 2025)
Small‑scale fed‑batch cultivations of Vibrio natriegens: overcoming challenges for early process development (Clara Lüchtrath et al., Bioprocess and Biosystems Engineering 2025)
Online monitoring of the respiration activity in 96-deep-well microtiter plate Chinese hamster ovary cultures streamlines kill curve experiments (Anne Neuss et al., Biotechnology Progress 2024)
Unraveling the impact of pH, sodium concentration, and medium osmolality on Vibrio natriegens in batch processes (Eva Forsten et al., BMC Biotechnology 2024)
Investigation into struvite precipitation: A commonly encountered problem during fermentations on chemically defined media (Thomas Steimann et al., Biotechnology and Bioengineering 2023)
Unraveling the potential and constraints associated with corn steep liquor as a nutrient source for industrial fermentations (Sekar Mayang W. Wahjudi et al., Biotechnology Progress 2023)
Predicting high recombinant protein producer strains of Pichia pastoris MutS using the oxygen transfer rate as an indicator of metabolic burden (David Wollborn et al., Scientific reports 2022)
Device for respiration activity measurement enables the determination of oxygen transfer rates of microbial cultures in shaken 96-deepwell microtiter plates (Robert Dinger et al., Biotechnology and Bioengineering 2021)
Experimental kS estimation: A comparison of methods for Corynebacterium glutamicum from lab to microfluidic scale (Heiko Steinhoff et al., Biotechnology and Bioengineering 2023)
Phosphate limitation enhances malic acid production on nitrogen‑rich molasseswith Ustilago trichophora
(Luca Antonia Grebe et al., Biotechnology for Biofuels and Bioproducts 2024)
The following flyers provide information about the machines and function-specific solutions.
Kuhner shakers are suitable for the cultivation of microbial, plant, human and animal cell cultures. Find more information about the different application areas and suitable product recommendations for optimal cultivation here.
Adolf Kühner AG (Headquarters)
Dinkelbergstrasse 1
CH-4127 Birsfelden (Basel)
Switzerland
We support our customers in implementation, maintenance and repair of all Kuhner products – efficiently and competently.
For Kuhner, the quality and durability of their shakers and bioreactors have always been the topics with the highest priority. On this account, Kuhner products have also proven their worth worldwide under GMP requirements. Documentation, development and production along the full life cycle of our products are continuously enhanced to match the requirements of 21 CFR and GAMP 5.
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The world's most reliable shaking machines built in-house in Switzerland.
