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Kuhner ScienceNote

Die ScienceNote vermittelt anschaulich und prägnant wissenschaftliche Ergebnisse von Arbeiten und Experimenten mit Kühner Produkten (Schüttler, FeedingTechnology, geschüttelte Bioreaktorsysteme, …). Dafür arbeiten wir eng mit Partnern aus Industrie und Hochschulforschung zusammen:

Zürcher Hochschule für Angewandte Wissenschaften ZHAW

École Polytechnique Fédérale de Lausanne EPFL

Rheinisch-Westfälische Technische Hochschule Aachen RWTH

Technische Universität Hamburg-Harburg TUHH

Universitat Autònoma de Barcelona

UCL Engineering

Massachusetts Institute of Technology

Fraunhofer Institute for Molecular Biology and Applied Ecology IME

ExcellGene

Dr. Shaker

Zellkultur

Characterisation of a
RSB 20 L

Characterisation of
SB10-X single-use
bioreactor

Determination of
scale parameters in
shaken bioreactors

Distribution and mixing
times of microcarriers

Evaporation and Aeration
in Shaken Bioreactors

Fluid flow and mixing
dynamics in a shaken
bioreactor

Monitoring of pH and
OTR using a multiple
shake flask platform

New Orbital Single Use
Bioreactor

Orbital Mixing as an
Alternative to Stirred-Tank
Bioreactors

Orbital Shaken
Bioreactors
The Scale Up Fast Track

Online measurement
New applications

Scale-up 1

Scale-up 2

Scale-up 3

Disposable orbitally
shaken TubeSpinÂ®
bioreactor 600

CO2 pH control without
probes in shaken
mammalian cell cultures

Characterization of
orbitally shaken single-
use bioreactors

Fed-batch Mode
in Shake Flasks

Baculovirus-based
r-protein production
in orbitally SUB

Oxygen Transport
Phenomena in Single-
Use Shaking Flasks

BEVS Insect Cells
Protein Production

Mammalian Cell Cultivation
using AerationCaps for
Shake Flask Gas Supply

Kuhner TOM for off-gas
analysis in shake flasks

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein in a Fed-Batch process

Automation of a cell culture process with larger vessels

Examining the respiratory activity of CHO cell pool expressing SARS-CoV-2 spike protein across shake flask scales using the TOM system

Scale up from shake flask
to orbital shaken bioreactors

Off-gas analysis of
Komagataella phaffii on
different carbon sources

Impact of protein production
on metabolic activity of CHO
stable cell line producing palivizumab

Mikrobiell

FeadBeads COSBIOS

Kuhner
Feeding Technology

Online measurement
New applications

Fed-Batch
Micro Plates

Cultivation of
entomopathogenic fungi
in orbitally shaken
bioreactors

Simple shake flask
cultivation of
Komagataella phaffii
with constant glycerol feed

Kuhner TOM for off-gas
analysis in shake flasks

Pflanzen

Fluid flow and mixing
dynamics in a shaken
bioreactor

Scale-up Production of
Pharmaceutical Proteins
in Plant Cell Suspensions

Engineering

Characterisation of a
RSB 20 L

Characterisation of
SB10-X single-use
bioreactor

COSBIOS

Determination of
scale parameters in
shaken bioreactors

Distribution and mixing
times of microcarriers

Evaporation and Aeration
in Shaken Bioreactors

Fluid flow and mixing
dynamics in a shaken
bioreactor

Monitoring of pH and
OTR using a multiple
shake flask platform

New Orbital Single Use
Bioreactor

Orbital Mixing as an
Alternative to Stirred-Tank
Bioreactors

Orbital Shaken
Bioreactors
The Scale Up Fast Track

Online Measurement
New applications

Scale-up 1

Scale-up 2

CO2 pH control without
probes in shaken
mammalian cell cultures

Characterization of
orbitally shaken single-
use bioreactors

Geheimnis des
Schüttelkolbens

Mechanistische Model-
lierung der Flüssigkeits-
verteilung in
Schüttelreaktoren

Mixing Time in
Shaking Bioreactors

Online measurement 1

Online measurement 2

Shaken Small Scale
Culture Systems

Cultivation of
entomopathogenic fungi
in orbitally shaken
bioreactors

Oxygen Transport
Phenomena in Single-
Use Shaking Flasks

BEVS Insect Cells
Protein Production

Mammalian Cell Cultivation
using AerationCaps for
Shake Flask Gas Supply

Kuhner TOM for off-gas
analysis in shake flasks

Mikrotiterplatten

Kuhner
Feeding Technology

Online measurement
New applications

Fed-Batch
Micro Plates

Kolben

Determination of
scale parameters in
shaken bioreactors

Evaporation and Aeration
in Shaken Bioreactors

Kuhner
Feeding Technology

Monitoring of pH and
OTR using a multiple
shake flask platform

New Orbital Single Use
Bioreactor

Orbital Mixing as an
Alternative to Stirred-Tank
Bioreactors

Orbital Shaken
Bioreactors
The Scale Up Fast Track

Online measurement
New applications

Scale-up Production of
Pharmaceutical Proteins
in Plant Cell Suspensions

Scale-up 1

Scale-up 3

Fed-batch Mode
in Shake Flasks

Geheimnis des
Schüttelkolbens

Mechanistische Model-
lierung der Flüssigkeits-
verteilung in
Schüttelreaktoren

Mixing Time in
Shaking Bioreactors

Online measurement 1

Online measurement 2

Shaken Small Scale
Culture Systems

Cultivation of
entomopathogenic fungi
in orbitally shaken
bioreactors

Oxygen Transport
Phenomena in Single-
Use Shaking Flasks

BEVS Insect Cells
Protein Production

Mammalian Cell Cultivation
using AerationCaps for
Shake Flask Gas Supply

Kuhner TOM for off-gas
analysis in shake flasks

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein in a Fed-Batch process

Examining the respiratory activity of CHO cell pool expressing SARS-CoV-2 spike protein across shake flask scales using the TOM system

Off-gas analysis of
Komagataella phaffii on
different carbon sources

Impact of protein production
on metabolic activity of CHO
stable cell line producing palivizumab

Geschüttelter Bioreaktor

Characterisation of
SB10-X single-use
bioreactor

Distribution and mixing
times of microcarriers

Fluid flow and mixing
dynamics in a shaken
bioreactor

New Orbital Single Use
Bioreactor

Orbital Mixing as an
Alternative to Stirred-Tank
Bioreactors

Orbital Shaken
Bioreactors
The Scale Up Fast Track

Scale-up Production of
Pharmaceutical Proteins
in Plant Cell Suspensions

Scale-up 1

Scale-up 2

Scale-up 3

Characterization of
orbitally shaken single-
use bioreactors

Baculovirus-based
r-protein production
in orbitally SUB

Cultivation of
entomopathogenic fungi
in orbitally shaken
bioreactors

Real-time monitoring and comparative analysis for density and viability of CHO-M cell in SB10-X shaking bioreactor using the C-Netics

Inkubator

Determination of
scale parameters in
shaken bioreactors

Evaporation and Aeration
in Shaken Bioreactors

Monitoring of pH and
OTR using a multiple
shake flask platform

New Orbital Single Use
Bioreactor

Orbital Mixing as an
Alternative to Stirred-Tank
Bioreactors

Orbital Shaken
Bioreactors
The Scale Up Fast Track

Online measurement
New applications

Disposable orbitally
shaken TubeSpinÂ®
bioreactor 600

CO2 pH control without
probes in shaken
mammalian cell cultures

BEVS Insect Cells
Protein Production

Mammalian Cell Cultivation
using AerationCaps for
Shake Flask Gas Supply

Kuhner TOM for off-gas
analysis in shake flasks

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein in a Fed-Batch process

Examining the respiratory activity of CHO cell pool expressing SARS-CoV-2 spike protein across shake flask scales using the TOM system

Off-gas analysis of
Komagataella phaffii on
different carbon sources

Impact of protein production
on metabolic activity of CHO
stable cell line producing palivizumab

Linear

Characterisation of a
RSB 20 L

Online

Monitoring of pH and
OTR using a multiple
shake flask platform

Online measurement
New applications

Scale-up Production of
Pharmaceutical Proteins
in Plant Cell Suspensions

Online measurement 1

Online measurement 2

Kuhner TOM for off-gas
analysis in shake flasks

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein

TOM system for analyzing the respiratory activity of a CHO cell pool expressing SARS-CoV-2 Spike Protein in a Fed-Batch process

Examining the respiratory activity of CHO cell pool expressing SARS-CoV-2 spike protein across shake flask scales using the TOM system

Off-gas analysis of
Komagataella phaffii on
different carbon sources

Impact of protein production
on metabolic activity of CHO
stable cell line producing palivizumab

Feeding Technologie

Kuhner
Feeding Technology

Fed-Batch
Micro Plates

Fed-batch Mode
in Shake Flasks

Simple shake flask
cultivation of
Komagataella phaffii
with constant glycerol feed

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