Shake flasks have been a cornerstone of biotechnological research for nearly a century and remain one of the most commonly used cultivation systems for early-stage bioprocess development today. Despite the emergence of more sophisticated bioreactor systems, shake flasks continue to play a crucial role in microbial, fungal and mammalian cell culture research, as they offer cost efficiency, ease of handling and high experimental throughput. A recent review highlighted that the number of scientific publications mentioning shake flasks has been steadily increasing, with more than 20,000 papers per year referencing their use in screening and process development studies (Brauneck et al, 2025)...

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