Sterilisation with vaporised hydrogen peroxide (VHP; H₂O₂) is an economical and effective alternative to pure manual disinfection using isopropanol or similar substances and steam sterilisation, which is common practice in production processes.

VHP is especially worthwhile in situations where the capital cost of installing steam sterilisation equipment is too high, but the benefits of using a reproducible process are necessary. With the VHP method, the freeze dryer is connected to a suitable VHP generator in a closed loop, usually by means of hoses and quick-release couplings, so that the VHP generator can also be used as needed with other equipment.